Reaction Details | |||
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Target | P2X purinoceptor 4 | ||
Ligand | BDBM50370141 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_876885 (CHEMBL2184479) | ||
IC50 | 15200±n/a nM | ||
Citation | Hernandez-Olmos, V; Abdelrahman, A; El-Tayeb, A; Freudendahl, D; Weinhausen, S; Müller, CE N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists. J Med Chem55:9576-88 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
P2X purinoceptor 4 | |||
Name: | P2X purinoceptor 4 | ||
Synonyms: | ATP receptor | P2RX4 | P2RX4_HUMAN | P2X4 | Purinergic receptor | Purinergic, P2X4 | ||
Type: | Enzyme Catalytic Domain | ||
Mol. Mass.: | 43374.70 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Purinergic, P2X4 0 HUMAN::Q99571 | ||
Residue: | 388 | ||
Sequence: |
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BDBM50370141 | |||
n/a | |||
Name | BDBM50370141 | ||
Synonyms: | TNP-ATP | ||
Type | Small organic molecule | ||
Emp. Form. | C16H16N8O19P3 | ||
Mol. Mass. | 717.2623 | ||
SMILES | Nc1ncnc2n(cnc12)C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C2OC3(OC12)C(=C[C-](C=C3[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O |c:36,39,(6.91,.64,;6.89,-.9,;5.56,-1.66,;5.55,-3.21,;6.88,-3.97,;8.21,-3.22,;9.67,-3.7,;10.58,-2.46,;9.68,-1.21,;8.22,-1.68,;10.14,-5.17,;9.23,-6.42,;10.13,-7.66,;9.36,-9,;7.82,-9.01,;7.06,-10.34,;5.72,-9.57,;8.15,-11.43,;5.96,-11.43,;4.42,-11.44,;4.39,-9.89,;3.66,-12.79,;2.92,-11.07,;1.38,-11.1,;.93,-9.62,;-.11,-11.54,;1.4,-12.64,;11.6,-7.19,;13.07,-7.68,;13.97,-6.42,;13.07,-5.18,;11.6,-5.65,;14.73,-7.75,;16.26,-7.76,;17.03,-6.44,;16.26,-5.11,;14.73,-5.1,;13.96,-3.76,;14.73,-2.42,;12.42,-3.75,;18.57,-6.45,;19.34,-5.11,;19.34,-7.79,;13.95,-9.09,;12.41,-9.08,;14.72,-10.43,)| | ||
Structure |