| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidylate synthase |
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| Ligand | BDBM50399275 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_877089 (CHEMBL2186825) |
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| IC50 | 619000±n/a nM |
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| Citation |  Carosati, E; Tochowicz, A; Marverti, G; Guaitoli, G; Benedetti, P; Ferrari, S; Stroud, RM; Finer-Moore, J; Luciani, R; Farina, D; Cruciani, G; Costi, MP Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase. J Med Chem55:10272-6 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidylate synthase |
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| Name: | Thymidylate synthase |
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| Synonyms: | TS | TSase | TYMS | TYSY_HUMAN | Thymidylate synthase (TS) | Thymidylate synthase/GAR transformylase/AICAR transformylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 35718.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 313 |
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| Sequence: | MPVAGSELPRRPLPPAAQERDAEPRPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFG
MQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDS
LGFSTREEGDLGPVYGFQWRHFGAEYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMC
AWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHI
TGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEG
YNPHPTIKMEMAV
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| BDBM50399275 |
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| n/a |
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| Name | BDBM50399275 |
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| Synonyms: | CHEMBL1973426 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20N4O6 |
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| Mol. Mass. | 376.3639 |
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| SMILES | OCCNCCn1cc(C(=O)NC(=O)OCc2ccccc2)c(=O)[nH]c1=O |
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| Structure | 
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