| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform epsilon |
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| Ligand | BDBM50399656 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_878858 (CHEMBL2184571) |
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| IC50 | 32±n/a nM |
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| Citation |  Long, AM; Zhao, H; Huang, X Structural basis for the potent and selective inhibition of casein kinase 1 epsilon. J Med Chem55:10307-11 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform epsilon |
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| Name: | Casein kinase I isoform epsilon |
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| Synonyms: | Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Æ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 47340.25 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49674 |
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| Residue: | 416 |
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| Sequence: | MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQ
GGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIH
SKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYA
SINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL
CKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARN
PEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAG
NTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
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| BDBM50399656 |
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| n/a |
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| Name | BDBM50399656 |
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| Synonyms: | CHEMBL2069623 | US11633415, Compound PF4800567 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H18ClN5O2 |
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| Mol. Mass. | 359.81 |
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| SMILES | Nc1ncnc2n(nc(COc3cccc(Cl)c3)c12)C1CCOCC1 |
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| Structure | 
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