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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | 5-hydroxytryptamine receptor 3A | ||
| Ligand | BDBM50173952 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_877364 (CHEMBL2182409) | ||
| Ki | 49.8±n/a nM | ||
| Citation |  Mazurov, AA; Kombo, DC; Hauser, TA; Miao, L; Dull, G; Genus, JF; Fedorov, NB; Benson, L; Sidach, S; Xiao, Y; Hammond, PS; James, JW; Miller, CH; Yohannes, D Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selectivea7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders. J Med Chem55:9793-809 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| 5-hydroxytryptamine receptor 3A | |||
| Name: | 5-hydroxytryptamine receptor 3A | ||
| Synonyms: | 5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3 | ||
| Type: | Protein | ||
| Mol. Mass.: | 55283.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P46098 | ||
| Residue: | 478 | ||
| Sequence: |
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| BDBM50173952 | |||
| n/a | |||
| Name | BDBM50173952 | ||
| Synonyms: | Benzo[b]thiophene-2-carboxylic acid (1-aza-bicyclo[2.2.2]oct-3-yl)-amide | CHEMBL365323 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C16H18N2OS | ||
| Mol. Mass. | 286.392 | ||
| SMILES | O=C(NC1CN2CCC1CC2)c1cc2ccccc2s1 |THB:2:3:9.10:7.6,(2.61,.02,;2.05,-1.43,;.52,-1.65,;-.44,-.43,;-.73,.98,;-2.08,1.59,;-2.02,3.23,;-1.56,2.11,;-1.82,.21,;-3.37,-.45,;-3.58,.93,;3.01,-2.63,;2.59,-4.13,;3.87,-4.99,;4.09,-6.52,;5.52,-7.09,;6.74,-6.13,;6.52,-4.6,;5.09,-4.03,;4.55,-2.58,)| | ||
| Structure | 
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