Reaction Details | |||
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Target | Neuronal acetylcholine receptor subunit alpha-7 | ||
Ligand | BDBM50393248 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_877369 (CHEMBL2182414) | ||
EC50 | 60±n/a nM | ||
Citation | Mazurov, AA; Kombo, DC; Hauser, TA; Miao, L; Dull, G; Genus, JF; Fedorov, NB; Benson, L; Sidach, S; Xiao, Y; Hammond, PS; James, JW; Miller, CH; Yohannes, D Discovery of (2S,3R)-N-[2-(Pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selectivea7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders. J Med Chem55:9793-809 (2012) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Neuronal acetylcholine receptor subunit alpha-7 | |||
Name: | Neuronal acetylcholine receptor subunit alpha-7 | ||
Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) | ||
Type: | Enzyme | ||
Mol. Mass.: | 56502.44 | ||
Organism: | Rattus norvegicus (Rat) | ||
Description: | Q05941 | ||
Residue: | 502 | ||
Sequence: |
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BDBM50393248 | |||
n/a | |||
Name | BDBM50393248 | ||
Synonyms: | CHEMBL1258005 | ||
Type | Small organic molecule | ||
Emp. Form. | C20H22BrN3O | ||
Mol. Mass. | 400.312 | ||
SMILES | Brc1ccc(cc1)C(=O)N[C@@H]1C2CCN(CC2)[C@H]1Cc1cccnc1 |r,wU:10.10,wD:17.20,TLB:18:17:13.12:15.16,THB:9:10:13.12:15.16,(-.69,-12.68,;-2.04,-13.43,;-2.06,-14.97,;-3.4,-15.72,;-4.72,-14.94,;-4.71,-13.4,;-3.37,-12.64,;-6.06,-15.69,;-6.08,-17.23,;-7.38,-14.9,;-8.73,-15.65,;-10.2,-15.01,;-11.56,-15.62,;-11.84,-17.01,;-10.46,-16.38,;-10.71,-14.48,;-10.27,-13.37,;-8.92,-17.03,;-8.16,-18.37,;-8.94,-19.7,;-10.48,-19.68,;-11.28,-21.01,;-10.51,-22.35,;-8.96,-22.36,;-8.18,-21.03,)| | ||
Structure |