| Reaction Details |
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 | Report a problem with these data |
| Target | dTMP kinase |
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| Ligand | BDBM50223806 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_877484 (CHEMBL2183638) |
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| Ki | 31000±n/a nM |
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| Citation |  Cui, H; Carrero-Lérida, J; Silva, AP; Whittingham, JL; Brannigan, JA; Ruiz-Pérez, LM; Read, KD; Wilson, KS; González-Pacanowska, D; Gilbert, IH Synthesis and evaluation ofa-thymidine analogues as novel antimalarials. J Med Chem55:10948-57 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| dTMP kinase |
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| Name: | dTMP kinase |
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| Synonyms: | TMK | Thymidylate kinase, putative |
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| Type: | PROTEIN |
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| Mol. Mass.: | 24691.81 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_877484 |
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| Residue: | 210 |
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| Sequence: | MTDDKKKGKFIVFEGLDRSGKSTQSKLLVEYLKNNNVEVKHLYFPNRETGIGQIISKYLK
MENSMSNETIHLLFSANRWEHMNEIKSLLLKGIWVVCDRYAYSGVAYSSGALNLNKTWCM
NPDQGLIKPDVVFYLNVPPNYAQNRSDYGEEIYEKVETQKKIYETYKHFAHEDYWINIDA
TRKIEDIHNDIVKEVTKIKVEPEEFNFLWS
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| BDBM50223806 |
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| n/a |
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| Name | BDBM50223806 |
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| Synonyms: | CHEMBL392137 | N-(5'-deoxy-alpha-D-thymidin-5'-yl)-N'-(3-trifluoromethyl-4-chlorophenyl)thiourea |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18ClF3N4O4S |
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| Mol. Mass. | 478.873 |
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| SMILES | Cc1cn([C@@H]2C[C@H](O)[C@@H](CNC(=S)Nc3ccc(Cl)c(c3)C(F)(F)F)O2)c(=O)[nH]c1=O |
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| Structure | 
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