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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | GTPase KRas | ||
| Ligand | BDBM50101929 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_879209 (CHEMBL2208522) | ||
| EC50 | >10000±n/a nM | ||
| Citation |  Marsault, E; Peterson, ML Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery. J Med Chem54:1961-2004 (2011) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| GTPase KRas | |||
| Name: | GTPase KRas | ||
| Synonyms: | GTPase KRas, N-terminally processed | K-Ras 2 | KRAS | KRAS2 | Ki-Ras | RASK2 | RASK_HUMAN | c-K-ras | c-Ki-ras | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 21656.10 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1476955 | ||
| Residue: | 189 | ||
| Sequence: |
| ||
| BDBM50101929 | |||
| n/a | |||
| Name | BDBM50101929 | ||
| Synonyms: | 3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,5.113,17.07,11.022,26]triaconta-1(26),7,9,13(30),14,16,19(27),20,22,24-decaen-16-yl cyanide | 3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,5.113,17.07,11.022,26]triaconta-1(26),7,9,13,15,17(30),19(27),20,22,24-decaen-16-yl cyanide | 4-{5-[4-(3-Chloro-phenyl)-3-oxo-piperazin-1-ylmethyl]-imidazol-1-ylmethyl}-benzonitrile | CHEMBL52073 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H21N5O2 | ||
| Mol. Mass. | 435.4772 | ||
| SMILES | O=C1CN2CCN1c1cccc3ccc(Oc4cc(Cn5cncc5C2)ccc4C#N)cc13 | ||
| Structure | 
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