Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50266889 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_879961 (CHEMBL2212410) |
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Ki | 0.6±n/a nM |
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Citation | Kumata, K; Yui, J; Hatori, A; Fujinaga, M; Yanamoto, K; Yamasaki, T; Kawamura, K; Wakizaka, H; Nengaki, N; Yoshida, Y; Ogawa, M; Fukumura, T; Zhang, MR Synthesis and evaluation of novel carbon-11 labeled oxopurine analogues for positron emission tomography imaging of translocator protein (18 kDa) in peripheral organs. J Med Chem54:6040-9 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50266889 |
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n/a |
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Name | BDBM50266889 |
Synonyms: | CHEMBL513922 | N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenyl-7H-purin-9(8H)-yl)acetamide |
Type | Small organic molecule |
Emp. Form. | C23H23N5O2 |
Mol. Mass. | 401.461 |
SMILES | CCN(Cc1ccccc1)C(=O)Cn1c2nc(ncc2n(C)c1=O)-c1ccccc1 |
Structure |
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