| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 26A1 |
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| Ligand | BDBM50401162 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_881496 (CHEMBL2214483) |
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| IC50 | 95±n/a nM |
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| Citation |  Gomaa, MS; Bridgens, CE; Illingworth, NA; Veal, GJ; Redfern, CP; Brancale, A; Armstrong, JL; Simons, C Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold. Bioorg Med Chem20:4201-7 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 26A1 |
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| Name: | Cytochrome P450 26A1 |
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| Synonyms: | CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 56216.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43174 |
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| Residue: | 497 |
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| Sequence: | MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM
VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL
GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE
VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR
NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG
GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI
KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM
LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV
YPVDNLPARFTHFHGEI
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| BDBM50401162 |
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| n/a |
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| Name | BDBM50401162 |
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| Synonyms: | CHEMBL2205776 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24N4O3 |
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| Mol. Mass. | 392.451 |
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| SMILES | COC(=O)C(C)(C)C(c1ccc(Nc2ccc(cc2)C(C)=O)cc1)n1cncn1 |
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| Structure | 
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