| Reaction Details |
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 | Report a problem with these data |
| Target | Excitatory amino acid transporter 3 |
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| Ligand | BDBM50401545 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_882147 (CHEMBL2214979) |
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| IC50 | >300000±n/a nM |
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| Citation |  Huynh, TH; Abrahamsen, B; Madsen, KK; Gonzalez-Franquesa, A; Jensen, AA; Bunch, L Design, synthesis and pharmacological characterization of coumarin-based fluorescent analogs of excitatory amino acid transporter subtype 1 selective inhibitors, UCPH-101 and UCPH-102. Bioorg Med Chem20:6831-9 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Excitatory amino acid transporter 3 |
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| Name: | Excitatory amino acid transporter 3 |
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| Synonyms: | EAA3_HUMAN | EAAC1 | EAAT3 | Excitatory Amino Acid EAAT3 | HEAAC1 | SLC1A1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57096.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Excitatory Amino Acid EAAT3 0 HUMAN::P43005 |
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| Residue: | 524 |
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| Sequence: | MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILM
RMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGV
TQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMT
EESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFF
NALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVI
LPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLP
VGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMV
IVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVN
IVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
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| BDBM50401545 |
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| n/a |
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| Name | BDBM50401545 |
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| Synonyms: | CHEMBL2207078 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H20N2O5 |
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| Mol. Mass. | 440.4474 |
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| SMILES | COc1ccc2c(cc(=O)oc2c1)C1C(C#N)C(=N)OC2=C1C(=O)CC(C2)c1ccccc1 |c:22| |
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| Structure | 
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