Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM50401620 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_887302 (CHEMBL2216281) |
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IC50 | 21±n/a nM |
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Citation | Lainchbury, M; Matthews, TP; McHardy, T; Boxall, KJ; Walton, MI; Eve, PD; Hayes, A; Valenti, MR; de Haven Brandon, AK; Box, G; Aherne, GW; Reader, JC; Raynaud, FI; Eccles, SA; Garrett, MD; Collins, I Discovery of 3-alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as selective, orally bioavailable CHK1 inhibitors. J Med Chem55:10229-40 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM50401620 |
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n/a |
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Name | BDBM50401620 |
Synonyms: | CHEMBL2204587 |
Type | Small organic molecule |
Emp. Form. | C17H20F3N7O |
Mol. Mass. | 395.3822 |
SMILES | CNc1cc(Nc2cnc(C#N)c(O[C@H](C)CN(C)C)n2)ncc1C(F)(F)F |r| |
Structure |
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