| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50401849 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_885380 (CHEMBL2215682) |
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| EC50 | 350±n/a nM |
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| Citation |  Pfefferkorn, JA; Tu, M; Filipski, KJ; Guzman-Perez, A; Bian, J; Aspnes, GE; Sammons, MF; Song, W; Li, JC; Jones, CS; Patel, L; Rasmusson, T; Zeng, D; Karki, K; Hamilton, M; Hank, R; Atkinson, K; Litchfield, J; Aiello, R; Baker, L; Barucci, N; Bourassa, P; Bourbounais, F; D'Aquila, T; Derksen, DR; MacDougall, M; Robertson, A The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus. Bioorg Med Chem Lett22:7100-5 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | Gck | HXK4_RAT | Hexokinase type IV |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52101.81 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1279785 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNN
IVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGE
LVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPS
VTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ
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| BDBM50401849 |
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| n/a |
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| Name | BDBM50401849 |
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| Synonyms: | CHEMBL2204663 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H22FN7O3 |
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| Mol. Mass. | 475.475 |
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| SMILES | CCn1cc2c(Oc3cnc(C(=O)N4CCC4)c(F)c3)cc(cc2n1)C(=O)Nc1cnc(C)cn1 |
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| Structure | 
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