Reaction Details |
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Target | Histamine H1 receptor |
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Ligand | BDBM50402111 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_884700 (CHEMBL2215148) |
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Ki | 2.51±n/a nM |
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Citation | Furber, M; Alcaraz, L; Luckhurst, C; Bahl, A; Beaton, H; Bowers, K; Collington, J; Denton, R; Donald, D; Kinchin, E; MacDonald, C; Rigby, A; Riley, R; Soars, M; Springthorpe, B; Webborn, P Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: optimising in vivo clearance. Bioorg Med Chem Lett22:7707-10 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H1 receptor |
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Name: | Histamine H1 receptor |
Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 55808.72 |
Organism: | Homo sapiens (Human) |
Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
Residue: | 487 |
Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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BDBM50402111 |
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n/a |
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Name | BDBM50402111 |
Synonyms: | CHEMBL2207657 |
Type | Small organic molecule |
Emp. Form. | C25H27ClFN3O4 |
Mol. Mass. | 487.951 |
SMILES | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3c(F)cccc23)CC1 |r| |
Structure |
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