| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 3 |
|---|
| Ligand | BDBM50402124 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_884699 (CHEMBL2215147) |
|---|
| Ki | 6.31±n/a nM |
|---|
| Citation |  Furber, M; Alcaraz, L; Luckhurst, C; Bahl, A; Beaton, H; Bowers, K; Collington, J; Denton, R; Donald, D; Kinchin, E; MacDonald, C; Rigby, A; Riley, R; Soars, M; Springthorpe, B; Webborn, P Discovery and evolution of phenoxypiperidine hydroxyamide dual CCR3/H1 antagonists. Part II: optimising in vivo clearance. Bioorg Med Chem Lett22:7707-10 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 3 |
|---|
| Name: | C-C chemokine receptor type 3 |
|---|
| Synonyms: | C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41053.88 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P51677 |
|---|
| Residue: | 355 |
|---|
| Sequence: | MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE
TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL
IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI
YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
|
|
|
|---|
| BDBM50402124 |
|---|
| n/a |
|---|
| Name | BDBM50402124 |
|---|
| Synonyms: | CHEMBL2207277 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H30ClN3O6S |
|---|
| Mol. Mass. | 548.051 |
|---|
| SMILES | Cc1cc(Cl)ccc1OC1CCN(C[C@H](O)CNC(=O)c2c[nH]c(=O)c3ccc(cc23)S(C)(=O)=O)CC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
