| Reaction Details |
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 | Report a problem with these data |
| Target | Advanced glycosylation end product-specific receptor |
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| Ligand | BDBM50402565 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_886755 (CHEMBL2210069) |
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| IC50 | 910±n/a nM |
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| Citation |  Lee, YS; Kim, H; Kim, YH; Roh, EJ; Han, H; Shin, KJ Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease. Bioorg Med Chem Lett22:7555-61 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Advanced glycosylation end product-specific receptor |
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| Name: | Advanced glycosylation end product-specific receptor |
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| Synonyms: | AGER | RAGE | RAGE_HUMAN | Receptor for advanced glycosylation end products |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42800.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1339877 |
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| Residue: | 404 |
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| Sequence: | MAAGTAVGAWVLVLSLWGAVVGAQNITARIGEPLVLKCKGAPKKPPQRLEWKLNTGRTEA
WKVLSPQGGGPWDSVARVLPNGSLFLPAVGIQDEGIFRCQAMNRNGKETKSNYRVRVYQI
PGKPEIVDSASELTAGVPNKVGTCVSEGSYPAGTLSWHLDGKPLVPNEKGVSVKEQTRRH
PETGLFTLQSELMVTPARGGDPRPTFSCSFSPGLPRHRALRTAPIQPRVWEPVPLEEVQL
VVEPEGGAVAPGGTVTLTCEVPAQPSPQIHWMKDGVPLPLPPSPVLILPEIGPQDQGTYS
CVATHSSHGPQESRAVSISIIEPGEEGPTAGSVGGSGLGTLALALGILGGLGTAALLIGV
ILWQRRQRRGEERKAPENQEEEEERAELNQSEEPEAGESSTGGP
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| BDBM50402565 |
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| n/a |
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| Name | BDBM50402565 |
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| Synonyms: | CHEMBL2205572 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H33ClN2O2S |
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| Mol. Mass. | 533.124 |
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| SMILES | CCCCc1sc(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)-c1ccc(OCCN2CCCC2)cc1 |
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| Structure | 
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