| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 7 |
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| Ligand | BDBM50336457 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_887642 (CHEMBL2217251) |
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| IC50 | 300±n/a nM |
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| Citation |  Barf, T; Kaptein, A Irreversible protein kinase inhibitors: balancing the benefits and risks. J Med Chem55:6243-62 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 7 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 7 |
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| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 7 | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) | JNKK2 | MAP2K7 | MEK7 | MKK7 | MP2K7_HUMAN | PRKMK7 | SKK4 |
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| Type: | Protein |
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| Mol. Mass.: | 47502.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14733 |
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| Residue: | 419 |
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| Sequence: | MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
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| BDBM50336457 |
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| n/a |
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| Name | BDBM50336457 |
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| Synonyms: | (3S,5Z,8S,9R,11E)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-benzo[c][1]oxacyclotetradecine-1,7(8H)-dione | CHEMBL1077979 | CHEMBL1668411 | CHEMBL1801950 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22O7 |
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| Mol. Mass. | 362.3738 |
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| SMILES | COc1cc(O)c2c(CCCC(=O)C(=O)C(=O)CCC[C@H](C)OC2=O)c1 |r| |
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| Structure | 
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