| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [489-587] |
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| Ligand | BDBM1150 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_36514 |
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| Ki | 0.020045±n/a nM |
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| Citation |  Katritzky, AR; Oliferenko, A; Lomaka, A; Karelson, M Six-membered cyclic ureas as HIV-1 protease inhibitors: a QSAR study based on CODESSA PRO approach. Quantitative structure-activity relationships. Bioorg Med Chem Lett12:3453-7 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Gag-Pol polyprotein [489-587] |
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| Name: | Gag-Pol polyprotein [489-587] |
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| Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 10781.16 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P04585[489-587] |
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| Residue: | 99 |
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| Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
|
|
|
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| BDBM1150 |
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| n/a |
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| Name | BDBM1150 |
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| Synonyms: | (4R,5R,6R)-Tetrahydro-1-(3-aminophenyl-methyl)-3-[(3-(N-hydroxycarboximidamide)phenyl-methyl]-4-(2-phenylethyl)-5-hydroxy-6-(phenylmethyl)-2(1H)-pyrimidinone | 3-{[(4R,5R,6R)-3-[(3-aminophenyl)methyl]-4-benzyl-5-hydroxy-2-oxo-6-(2-phenylethyl)-1,3-diazinan-1-yl]methyl}-N'-hydroxybenzene-1-carboximidamide | Tetrahydropyrimidinone deriv. 98 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H37N5O3 |
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| Mol. Mass. | 563.6893 |
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| SMILES | Nc1cccc(CN2[C@H](Cc3ccccc3)[C@H](O)[C@@H](CCc3ccccc3)N(Cc3cccc(c3)C(=N)NO)C2=O)c1 |r| |
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| Structure | 
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