| Reaction Details |
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 | Report a problem with these data |
| Target | Trypsin |
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| Ligand | BDBM50404147 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_212329 (CHEMBL857532) |
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| Ki | >5000±n/a nM |
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| Citation |  Chou, YL; Davey, DD; Eagen, KA; Griedel, BD; Karanjawala, R; Phillips, GB; Sacchi, KL; Shaw, KJ; Wu, SC; Lentz, D; Liang, AM; Trinh, L; Morrissey, MM; Kochanny, MJ Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors. Bioorg Med Chem Lett13:507-11 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Trypsin |
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| Name: | Trypsin |
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| Synonyms: | Serine protease 1/Trypsin-2/Trypsin-3 |
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| Type: | n/a |
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| Mol. Mass.: | n/a |
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| Description: | ASSAY_ID of ChEMBL is 2155713 |
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| Components: | This complex has 3 components. |
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| Component 1 |
| Name: | Serine protease 1 |
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| Synonyms: | Alpha-trypsin chain 1 | Alpha-trypsin chain 2 | Beta-trypsin | Cationic trypsinogen | PRSS1 | Serine protease 1 | TRP1 | TRY1 | TRY1_HUMAN | TRYP1 | Thrombin & trypsin | Trypsin | Trypsin I | Trypsin-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 26557.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07477 |
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| Residue: | 247 |
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| Sequence: | MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
|
|
|
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| Component 2 |
| Name: | Trypsin-2 |
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| Synonyms: | Anionic trypsinogen | PRSS2 | Serine protease 2 | TRY2 | TRY2_HUMAN | TRYP2 | Thrombin & trypsin | Trypsin | Trypsin II | Trypsin-2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 26479.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_41517 |
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| Residue: | 247 |
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| Sequence: | MNLLLILTFVAAAVAAPFDDDDKIVGGYICEENSVPYQVSLNSGYHFCGGSLISEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPKYNSRTLDNDILLIKLSSPAVIN
SRVSAISLPTAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKIT
NNMFCVGFLEGGKDSCQGDSGGPVVSNGELQGIVSWGYGCAQKNRPGVYTKVYNYVDWIK
DTIAANS
|
|
|
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| Component 3 |
| Name: | Trypsin-3 |
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| Synonyms: | Brain trypsinogen | Mesotrypsinogen | PRSS3 | PRSS4 | Serine protease 3 | Serine protease 4 | TRY3 | TRY3_HUMAN | TRY4 | Thrombin & trypsin | Trypsin | Trypsin III | Trypsin IV | Trypsin-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32532.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_216043 |
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| Residue: | 304 |
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| Sequence: | MCGPDDRCPARWPGPGRAVKCGKGLAAARPGRVERGGAQRGGAGLELHPLLGGRTWRAAR
DADGCEALGTVAVPFDDDDKIVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAH
CYKTRIQVRLGEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARV
STISLPTTPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSM
FCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKDTI
AANS
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|
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| BDBM50404147 |
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| n/a |
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| Name | BDBM50404147 |
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| Synonyms: | CHEMBL422844 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16Cl2N2O4S2 |
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| Mol. Mass. | 483.388 |
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| SMILES | Cc1ccc(NC(=O)c2scc(c2Cl)S(C)(=O)=O)c(c1)C(=O)Nc1ccc(Cl)cc1 |
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| Structure | 
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