| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H2 receptor |
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| Ligand | BDBM50405173 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_85332 (CHEMBL694843) |
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| Kd | 213.8±n/a nM |
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| Citation |  Durant, GJ; Ganellin, CR; Hills, DW; Miles, PD; Parsons, ME; Pepper, ES; White, GR The histamine H2 receptor agonist impromidine: synthesis and structure-activity considerations. J Med Chem28:1414-22 (1985) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H2 receptor |
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| Name: | Histamine H2 receptor |
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| Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40567.22 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | For the H2 receptor-binding assays, guinea pig striatum was used. |
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| Residue: | 359 |
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| Sequence: | MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSL
AVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYH
QLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
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| BDBM50405173 |
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| n/a |
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| Name | BDBM50405173 |
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| Synonyms: | CHEMBL545393 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H25N7S2 |
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| Mol. Mass. | 367.536 |
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| SMILES | Cc1nc[nH]c1CSCCNC(=N)NCCSCc1[nH]cnc1C |
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| Structure | 
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