| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50081910 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_54926 |
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| Ki | 5012±n/a nM |
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| Citation |  Selassie, CD; Fang, ZX; Li, RL; Hansch, C; Debnath, G; Klein, TE; Langridge, R; Kaufman, BT On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships. J Med Chem32:1895-905 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_LACCA | dhfR | folA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 18437.08 |
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| Organism: | Lactobacillus casei |
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| Description: | ChEMBL_1357878 |
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| Residue: | 163 |
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| Sequence: | MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
|
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|
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| BDBM50081910 |
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| n/a |
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| Name | BDBM50081910 |
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| Synonyms: | 5-(3-Octyloxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL31235 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H28N4O |
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| Mol. Mass. | 328.4518 |
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| SMILES | CCCCCCCCOc1cccc(Cc2cnc(N)nc2N)c1 |
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| Structure | 
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