| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50110758 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_53614 |
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| Ki | 18197±n/a nM |
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| Citation |  Selassie, CD; Fang, ZX; Li, RL; Hansch, C; Debnath, G; Klein, TE; Langridge, R; Kaufman, BT On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships. J Med Chem32:1895-905 (1989) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | 1.5.1.3 | DHFR | DYR_CHICK |
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| Type: | n/a |
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| Mol. Mass.: | 21652.69 |
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| Organism: | Gallus gallus (Chicken) |
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| Description: | n/a |
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| Residue: | 189 |
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| Sequence: | VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSI
PEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAV
YKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFE
VYQKSVLAQ
|
|
|
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| BDBM50110758 |
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| n/a |
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| Name | BDBM50110758 |
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| Synonyms: | 5-(4-(benzyloxy)-3-ethoxybenzyl)pyrimidine-2,4-diamine | 5-(4-Benzyloxy-3-ethoxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL21395 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22N4O2 |
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| Mol. Mass. | 350.4143 |
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| SMILES | CCOc1cc(Cc2cnc(N)nc2N)ccc1OCc1ccccc1 |
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| Structure | 
|
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