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Target5-hydroxytryptamine receptor 3A/3B
LigandBDBM82561
Substrate/Competitorn/a
Meas. Tech.ChEMBL_3112 (CHEMBL620590)
Kd 6.2±n/a nM
Citation Hibert, MFHoffmann, RMiller, RCCarr, AA Conformation-activity relationship study of 5-HT3 receptor antagonists and a definition of a model for this receptor site. J Med Chem33:1594-600 (1990) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 3A/3B
Name:5-hydroxytryptamine receptor 3A/3B
Synonyms:Serotonin 3 receptor (5HT3)
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 357762
Components:This complex has 2 components.
Component 1
Name:5-hydroxytryptamine receptor 3A
Synonyms:5-HT-3 | 5-HT3-A | 5-HT3A | 5-HT3A Serotonin Receptor | 5-HT3R | 5-hydroxytryptamine receptor 3 | 5-hydroxytryptamine receptor 3A | 5HT3A_MOUSE | 5ht3 | Htr3 | Htr3a | Serotonin 3 receptor (5HT3) | Serotonin 3a (5-HT3a) receptor | Serotonin receptor 3A | Serotonin-gated ion channel receptor
Type:n/a
Mol. Mass.:56056.00
Organism:Mus musculus (house mouse)
Description:5HT3A
Residue:487
Sequence:
MRLCIPQVLLALFLSMLTAPGEGSRRRATQEDTTQPALLRLSDHLLANYKKGVRPVRDWR
KPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIW
VPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFT
SWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYV
IIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLP
ATIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILCL
GEQPMAHRPPATFQANKTDDCSGSDLLPAMGNHCSHVGGPQDLEKTPRGRGSPLPPPREA
SLAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTL
WSIWHYS
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Component 2
Name:5-hydroxytryptamine receptor 3B
Synonyms:5HT3B_MOUSE | Htr3b | Serotonin 3 receptor (5HT3) | Serotonin 3b (5-HT3b) receptor
Type:PROTEIN
Mol. Mass.:50317.35
Organism:Mus musculus
Description:ChEMBL_3121
Residue:437
Sequence:
MILLWSCLLVAVVGILGTATPQPGNSSLHRLTRQLLQQYHKEVRPVYNWAEATTVYLDLC
VHAVLDVDVQNQKLKTSVWYREVWNDEFLSWNSSLFDEIQEISLPLSALWAPDIIINEFV
DVERSPDLPYVYVNSSGTIRNHKPIQVVSACSLQTYAFPFDIQNCSLTFNSILHTVEDID
LGFLRNREDIENDKRAFMNDSEWQLLSVSSTYHIRQSSAGDFAQIRFNVVIRRCPLAYVV
SLLIPSIFLMLVDLGSFYLPPNCRARIVFKTNVLVGYTVFRVNMSDEVPRSAGCTPLIGV
FFTVCMALLVLSLSKSILLIKFLYEERHSGQERPLMCLQGDSDAEESRLYLGAPRADVTE
SPVHQEHRVPSDTLKDFWFQFRSINNSLRTRDQIHQKEVEWLAILYRFDQLLFRIYLAVL
GLYTVTLCSLWALWSRM
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BDBM82561
n/a
NameBDBM82561
Synonyms:CAS_40796-97-2 | TROPANYL 3,5-DICHLOROBENZOATE | Tropanyl-3,5 dichlorobenzoate
TypeSmall organic molecule
Emp. Form.C15H17Cl2NO2
Mol. Mass.314.207
SMILESCN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)c1cc(Cl)cc(Cl)c1 |r|
Structure
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