Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50029760 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_54726 (CHEMBL668339) |
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Ki | 4.5±n/a nM |
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Citation | Selassie, CD; Li, RL; Poe, M; Hansch, C On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase. J Med Chem34:46-54 (1991) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | 1.5.1.3 | Dihydrofolate reductase | folA | t0090 |
Type: | PROTEIN |
Mol. Mass.: | 17976.56 |
Organism: | Salmonella enterica subsp. enterica serovar Typhi |
Description: | ChEMBL_13019 |
Residue: | 159 |
Sequence: | MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVVMGRHTWESIGRPLPGRKNI
IISSQPGTDDRVQWVKSVDEAIAACGDAPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
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BDBM50029760 |
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n/a |
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Name | BDBM50029760 |
Synonyms: | 5-[3,5-Dimethoxy-4-(2-methoxy-ethoxy)-benzyl]-pyrimidine-2,4-diamine | 5-[3,5-Dimethoxy-4-(2-methoxy-ethoxy)-benzyl]-pyrimidine-2,4-diamine(Tetroxoprim ) | CHEMBL32039 | Tetroxoprim |
Type | Small organic molecule |
Emp. Form. | C16H22N4O4 |
Mol. Mass. | 334.3703 |
SMILES | COCCOc1c(OC)cc(Cc2cnc(N)nc2N)cc1OC |
Structure |
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