| Reaction Details |
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 | Report a problem with these data |
| Target | B2 bradykinin receptor |
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| Ligand | BDBM50408045 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_40445 (CHEMBL652384) |
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| Kd | 0.49±n/a nM |
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| Citation |  Goodfellow, VS; Marathe, MV; Kuhlman, KG; Fitzpatrick, TD; Cuadrado, D; Hanson, W; Zuzack, JS; Ross, SE; Wieczorek, M; Burkard, M; Whalley, ET Bradykinin receptor antagonists containing N-substituted amino acids: in vitro and in vivo B(2) and B(1) receptor antagonist activity. J Med Chem39:1472-84 (1996) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B2 bradykinin receptor |
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| Name: | B2 bradykinin receptor |
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| Synonyms: | B2 BRADYKININ | B2 bradykinin receptor | B2R | BK-2 receptor | BKRB2_RAT | Bdkrb2 | Bradykinin B2 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44941.22 |
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| Organism: | RAT |
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| Description: | B2 BRADYKININ BDKRB2 RAT::P25023 |
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| Residue: | 396 |
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| Sequence: | MDTRSSLCPKTQAVVAVFWGPGCHLSTCIEMFNITTQALGSAHNGTFSEVNCPDTEWWSW
LNAIQAPFLWVLFLLAALENIFVLSVFCLHKTNCTVAEIYLGNLAAADLILACGLPFWAI
TIANNFDWLFGEVLCRVVNTMIYMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAK
LYSLVIWSCTLLLSSPMLVFRTMKDYREEGHNVTACVIVYPSRSWEVFTNMLLNLVGFLL
PLSIITFCTVRIMQVLRNNEMKKFKEVQTEKKATVLVLAVLGLFVLCWFPFQISTFLDTL
LRLGVLSGCWNERAVDIVTQISSYVAYSNSCLNPLVYVIVGKRFRKKSREVYQAICRKGG
CMGESVQMENSMGTLRTSISVDRQIHKLQDWAGNKQ
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| BDBM50408045 |
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| n/a |
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| Name | BDBM50408045 |
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| Synonyms: | CHEMBL2372278 |
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| Type | Small organic molecule |
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| Emp. Form. | C52H76N14O12S |
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| Mol. Mass. | 1121.311 |
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| SMILES | NC(=N)NCCCCC(=O)N1CCC[C@@H]1C(=O)N1C[C@@H](O)C[C@@H]1C(=O)NCC(=O)N[C@@H](Cc1cccs1)C(=O)N[C@@H](CO)C(=O)N1Cc2ccccc2C[C@@H]1C(=O)N(CC(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1CCCCC1 |
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| Structure | 
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