| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M3 |
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| Ligand | BDBM50408539 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_138975 (CHEMBL857564) |
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| Ki | 5754±n/a nM |
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| Citation |  Bolognesi, ML; Minarini, A; Budriesi, R; Cacciaguerra, S; Chiarini, A; Spampinato, S; Tumiatti, V; Melchiorre, C Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists. J Med Chem41:4150-60 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M3 |
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| Name: | Muscarinic acetylcholine receptor M3 |
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| Synonyms: | ACM3_RAT | Cholinergic, muscarinic M3 | Chrm-3 | Chrm3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 66086.66 |
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| Organism: | RAT |
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| Description: | Cholinergic, muscarinic M3 CHRM3 RAT::P08483 |
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| Residue: | 589 |
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| Sequence: | MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLG
GHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVIS
MNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRT
TKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFY
MPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVK
RSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSET
RAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQ
KDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRM
SLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNP
VCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
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| BDBM50408539 |
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| n/a |
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| Name | BDBM50408539 |
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| Synonyms: | CHEMBL407678 |
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| Type | Small organic molecule |
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| Emp. Form. | C64H73N13O8 |
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| Mol. Mass. | 1152.3467 |
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| SMILES | CN(CCCCCCCCN(C)C(=O)CCCCCN(CC(=O)N1c2ccccc2C(=O)Nc2cccnc12)CC(=O)N1c2ccccc2C(=O)Nc2cccnc12)C(=O)CCCCCNCC(=O)N1c2ccccc2C(=O)Nc2cccnc12 |
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| Structure | 
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