Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50060105 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_37806 (CHEMBL651181) |
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IC50 | 1.82±n/a nM |
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Citation | Trapani, G; Franco, M; Latrofa, A; Ricciardi, L; Carotti, A; Serra, M; Sanna, E; Biggio, G; Liso, G Novel 2-phenylimidazo[1,2-a]pyridine derivatives as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity, and in vivo studies. J Med Chem42:3934-41 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50060105 |
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n/a |
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Name | BDBM50060105 |
Synonyms: | 2-[8-Chloro-2-(4-chloro-phenyl)-6-trifluoromethyl-imidazo[1,2-a]pyridin-3-yl]-N,N-dipropyl-acetamide | CHEMBL104686 |
Type | Small organic molecule |
Emp. Form. | C22H22Cl2F3N3O |
Mol. Mass. | 472.331 |
SMILES | CCCN(CCC)C(=O)Cc1c(nc2c(Cl)cc(cn12)C(F)(F)F)-c1ccc(Cl)cc1 |
Structure |
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