| Reaction Details |
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 | Report a problem with these data |
| Target | Histidine-rich protein PFHRP-II |
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| Ligand | BDBM22985 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_155111 (CHEMBL763685) |
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| IC50 | 15000±n/a nM |
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| Citation |  Vippagunta, SR; Dorn, A; Matile, H; Bhattacharjee, AK; Karle, JM; Ellis, WY; Ridley, RG; Vennerstrom, JL Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth. J Med Chem42:4630-9 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histidine-rich protein PFHRP-II |
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| Name: | Histidine-rich protein PFHRP-II |
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| Synonyms: | HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II |
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| Type: | PROTEIN |
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| Mol. Mass.: | 35156.49 |
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| Organism: | Plasmodium falciparum |
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| Description: | ChEMBL_500704 |
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| Residue: | 332 |
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| Sequence: | MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHA
HHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHA
ADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYA
HHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHA
ADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAH
HATDAHHAAAHHATDAHHAAAHHEAATHCLRH
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|
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| BDBM22985 |
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| n/a |
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| Name | BDBM22985 |
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| Synonyms: | Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chlorochin | Chloroquine | Chloroquine, 17 | med.21724, Compound 8 | {4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine |
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| Type | Antimalarial |
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| Emp. Form. | C18H26ClN3 |
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| Mol. Mass. | 319.872 |
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| SMILES | CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 |
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| Structure | 
|
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