Reaction Details |
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Target | Gag-Pol polyprotein [489-587] |
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Ligand | BDBM50005389 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_158030 (CHEMBL768621) |
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IC50 | 34±n/a nM |
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Citation | Vieth, M; Cummins, DJ DoMCoSAR: a novel approach for establishing the docking mode that is consistent with the structure-activity relationship. Application to HIV-1 protease inhibitors and VEGF receptor tyrosine kinase inhibitors. J Med Chem43:3020-32 (2000) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Gag-Pol polyprotein [489-587] |
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Name: | Gag-Pol polyprotein [489-587] |
Synonyms: | Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 10781.16 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[489-587] |
Residue: | 99 |
Sequence: | PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD
QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
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BDBM50005389 |
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n/a |
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Name | BDBM50005389 |
Synonyms: | CHEMBL322221 |
Type | Small organic molecule |
Emp. Form. | C33H40N2O4 |
Mol. Mass. | 528.6817 |
SMILES | [H][C@](CC(O)[C@]([H])(Cc1ccccc1)NC(=O)OC(C)(C)C)(Cc1ccccc1)C(=O)N[C@@]1([H])CCc2ccccc12 |
Structure |
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