| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor |
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| Ligand | BDBM50116387 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_100271 (CHEMBL712013) |
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| EC50 | 380±n/a nM |
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| Citation |  von Rauch, M; Schlenk, M; Gust, R Effects of C2-alkylation, N-alkylation, and N,N'-dialkylation on the stability and estrogen receptor interaction of (4R,5S)/(4S,5R)-4,5-bis(4-hydroxyphenyl)-2-imidazolines. J Med Chem47:915-27 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor |
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| Name: | Estrogen receptor |
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| Synonyms: | ER | ER-alpha | ESR | ESR1 | ESR1_HUMAN | Estradiol receptor | Estrogen receptor | Estrogen receptor (ER alpha) | Estrogen receptor (ER-alpha) | Estrogen receptor alpha (ER alpha) | Estrogen receptor alpha (ER) | NR3A1 | Nuclear receptor subfamily 3 group A member 1 |
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| Type: | Protein |
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| Mol. Mass.: | 66230.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03372 |
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| Residue: | 595 |
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| Sequence: | MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
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| BDBM50116387 |
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| n/a |
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| Name | BDBM50116387 |
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| Synonyms: | 2-Chloro-4-[5-(2-chloro-4-hydroxy-phenyl)-4,5-dihydro-1H-imidazol-4-yl]-phenol | 3-chloro-4-[(4S,5R)-4-(2-chloro-4-hydroxyphenyl)-4,5-dihydro-1H-imidazol-5-yl]phenol | 3-chloro-4-[4-(2-chloro-4-hydroxyphenyl)-(4S,5R)-4,5-dihydro-1H-5-imidazolyl]phenol | 4,4'-((4S,5R)-4,5-dihydro-1H-imidazole-4,5-diyl)bis(3-chlorophenol) | CHEMBL114159 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12Cl2N2O2 |
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| Mol. Mass. | 323.174 |
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| SMILES | Oc1ccc([C@H]2NC=N[C@H]2c2ccc(O)cc2Cl)c(Cl)c1 |r,c:7| |
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| Structure | 
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