| Reaction Details |
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 | Report a problem with these data |
| Target | Heparanase |
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| Ligand | BDBM50165614 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_531583 (CHEMBL990587) |
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| IC50 | 302±n/a nM |
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| Citation |  Jalali-Heravi, M; Asadollahi-Baboli, M; Shahbazikhah, P QSAR study of heparanase inhibitors activity using artificial neural networks and Levenberg-Marquardt algorithm. Eur J Med Chem43:548-56 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heparanase |
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| Name: | Heparanase |
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| Synonyms: | Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61167.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_327900 |
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| Residue: | 543 |
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| Sequence: | MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI
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| BDBM50165614 |
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| n/a |
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| Name | BDBM50165614 |
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| Synonyms: | (2-{4-[3-((E)-3-Chloro-2-fluoro-phenyl)-acryloylamino]-3-fluoro-phenyl}-benzooxazol-5-yl)-acetic acid | 2-(2-(4-(3-(3-chloro-2-fluorophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acid | CHEMBL196395 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H15ClF2N2O4 |
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| Mol. Mass. | 468.837 |
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| SMILES | OC(=O)Cc1ccc2oc(nc2c1)-c1ccc(NC(=O)\C=C\c2cccc(Cl)c2F)c(F)c1 |
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| Structure | 
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