| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 4 |
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| Ligand | BDBM50412131 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_556321 (CHEMBL954056) |
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| Ki | 7943±n/a nM |
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| Citation |  Ward, SE; Eddershaw, PJ; Scott, CM; Gordon, LJ; Lovell, PJ; Moore, SH; Smith, PW; Starr, KR; Thewlis, KM; Watson, JM Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists. J Med Chem51:2887-90 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 4 |
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| Name: | 5-hydroxytryptamine receptor 4 |
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| Synonyms: | 5-HT-4 | 5-HT4 | 5-HT4S | 5-HT4a | 5-HT4b | 5-HT4c | 5-HT4d | 5-HT4hb | 5-hydroxytryptamine receptor 4 | 5-hydroxytryptamine receptor 4 (5-HT4) | 5HT4R_HUMAN | HTR4 | Serotonin (5-HT) receptor | Serotonin (5-HT3) receptor | Serotonin 4 (5-HT4) receptor | Serotonin Receptor 4 |
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| Type: | Enzyme |
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| Mol. Mass.: | 43767.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13639 |
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| Residue: | 388 |
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| Sequence: | MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIV
SLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYY
AICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSN
STYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRP
QSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWL
GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRD
AVECGGQWESQCHPPATSPLVAAQPSDT
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| BDBM50412131 |
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| n/a |
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| Name | BDBM50412131 |
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| Synonyms: | CHEMBL522708 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H33N3O3S |
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| Mol. Mass. | 479.634 |
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| SMILES | Cc1ccc2c(OCCN3CCC(Cc4cccc(c4)N4CCCS4(=O)=O)CC3)cccc2n1 |
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| Structure | 
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