Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50412131 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_556323 (CHEMBL954058) |
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Ki | 1585±n/a nM |
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Citation | Ward, SE; Eddershaw, PJ; Scott, CM; Gordon, LJ; Lovell, PJ; Moore, SH; Smith, PW; Starr, KR; Thewlis, KM; Watson, JM Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists. J Med Chem51:2887-90 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50412131 |
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n/a |
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Name | BDBM50412131 |
Synonyms: | CHEMBL522708 |
Type | Small organic molecule |
Emp. Form. | C27H33N3O3S |
Mol. Mass. | 479.634 |
SMILES | Cc1ccc2c(OCCN3CCC(Cc4cccc(c4)N4CCCS4(=O)=O)CC3)cccc2n1 |
Structure |
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