| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50412452 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_536770 (CHEMBL984564) |
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| Ki | 676.08±n/a nM |
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| Citation |  Morini, G; Comini, M; Rivara, M; Rivara, S; Bordi, F; Plazzi, PV; Flammini, L; Saccani, F; Bertoni, S; Ballabeni, V; Barocelli, E; Mor, M Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity. Bioorg Med Chem16:9911-24 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48607.98 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50412452 |
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| n/a |
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| Name | BDBM50412452 |
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| Synonyms: | CHEMBL212869 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H40N2 |
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| Mol. Mass. | 404.6306 |
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| SMILES | CC1CC(C)CN(Cc2ccc(cc2)-c2ccc(CN3CC(C)CC(C)C3)cc2)C1 |
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| Structure | 
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