| Reaction Details |
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 | Report a problem with these data |
| Target | Acetylcholinesterase |
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| Ligand | BDBM50412454 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_536575 (CHEMBL988036) |
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| IC50 | 6760.83±n/a nM |
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| Citation |  Morini, G; Comini, M; Rivara, M; Rivara, S; Bordi, F; Plazzi, PV; Flammini, L; Saccani, F; Bertoni, S; Ballabeni, V; Barocelli, E; Mor, M Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity. Bioorg Med Chem16:9911-24 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acetylcholinesterase |
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| Name: | Acetylcholinesterase |
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| Synonyms: | ACES_RAT | Acetylcholinesterase (AChE) | Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) | Acetylcholinesterase precursor | Acetylcholinesterase, AChE | Ache |
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| Type: | Enzyme |
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| Mol. Mass.: | 68193.62 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P37136 |
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| Residue: | 614 |
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| Sequence: | MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPV
SAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSM
NYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASV
GMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTEL
ISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPDALINTGDFQDLQVLVG
VVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPE
DPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGY
EIEFIFGLPLDPSLNYTVEERIFAQRLMQYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQ
YVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQERCSDL
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| BDBM50412454 |
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| n/a |
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| Name | BDBM50412454 |
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| Synonyms: | CHEMBL458722 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H38N2 |
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| Mol. Mass. | 378.5933 |
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| SMILES | CCCN(CCC)Cc1ccc(cc1)-c1ccc(CCN2CCCCC2)cc1 |
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| Structure | 
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