| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H2 receptor |
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| Ligand | BDBM50412449 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_536583 (CHEMBL988044) |
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| EC50 | 3388.44±n/a nM |
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| Citation |  Morini, G; Comini, M; Rivara, M; Rivara, S; Bordi, F; Plazzi, PV; Flammini, L; Saccani, F; Bertoni, S; Ballabeni, V; Barocelli, E; Mor, M Synthesis and structure-activity relationships for biphenyl H3 receptor antagonists with moderate anti-cholinesterase activity. Bioorg Med Chem16:9911-24 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H2 receptor |
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| Name: | Histamine H2 receptor |
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| Synonyms: | Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_CAVPO | Histamine H2-Gs alpha S |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40567.22 |
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| Organism: | Cavia porcellus (domestic guinea pig) |
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| Description: | For the H2 receptor-binding assays, guinea pig striatum was used. |
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| Residue: | 359 |
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| Sequence: | MAFNGTVPSFCMDFTVYKVTISVILIILILVTVAGNVVVCLAVGLNRRLRSLTNCFIVSL
AVTDLLLGLLVLPFSAIYQLSCKWSFSKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
TDPLRYPVLITPARVAISLVFIWVISITLSFLSIHLGWNSRNETSKDNDTIVKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYFRIFKIAREQARRINHIGSWKAATIREHKATVTLAAVM
GAFIICWFPYFTVFVYRGLKGDDAVNEVFEDVVLWLGYANSALNPILYAALNRDFRTAYH
QLFCCRLASHNSHETSLRLNNSQLNRSQCQEPRWQEDKPLNLQVWSGTEVTAPQGATNR
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| BDBM50412449 |
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| n/a |
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| Name | BDBM50412449 |
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| Synonyms: | CHEMBL458718 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H40N2 |
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| Mol. Mass. | 380.6092 |
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| SMILES | CCCN(CCC)Cc1ccc(cc1)-c1ccc(CN(CCC)CCC)cc1 |
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| Structure | 
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