| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Amine oxidase [flavin-containing] A |
|---|
| Ligand | BDBM50412879 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_515032 (CHEMBL980843) |
|---|
| IC50 | 1000±n/a nM |
|---|
| Citation |  Chimenti, F; Fioravanti, R; Bolasco, A; Manna, F; Chimenti, P; Secci, D; Rossi, F; Turini, P; Ortuso, F; Alcaro, S; Cardia, MC Synthesis, molecular modeling studies and selective inhibitory activity against MAO of N1-propanoyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives. Eur J Med Chem43:2262-7 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Amine oxidase [flavin-containing] A |
|---|
| Name: | Amine oxidase [flavin-containing] A |
|---|
| Synonyms: | AOFA_BOVIN | Amine oxidase [flavin-containing] A | MAO-A | MAOA | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A | Monoamine oxidase type A |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 59764.63 |
|---|
| Organism: | Bos taurus |
|---|
| Description: | ChEMBL_1501477 |
|---|
| Residue: | 527 |
|---|
| Sequence: | MESLQKTSDAGQMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARERVGGRTYTVRNEHV
DYVDVGGAYVGPTQNRILRLSKQLGLETYKVNVNERLVHYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTMDNMGKEIPADAPWEAPHAVEWDKMTMKDLIEKICWTKTARQFASLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMQLLGDRVKL
RSPVTYVDQSSENITVETLNRELYECRYVISAIPPTLTAKIHFRPELPSERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSLPAIMGFILARKADR
LAKVHKDIRKRKICELYAKVLGSQEALHPVHYEEKNWCQEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKLSAKDIWIQEPEAED
VPAVEITPSFWERNLPSVSGLLKIVGFSTSITALWFVMYRFRLLSRS
|
|
|
|---|
| BDBM50412879 |
|---|
| n/a |
|---|
| Name | BDBM50412879 |
|---|
| Synonyms: | CHEMBL447022 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H19ClN2O2 |
|---|
| Mol. Mass. | 342.819 |
|---|
| SMILES | CCC(=O)N1N=C(CC1c1ccc(OC)cc1)c1ccc(Cl)cc1 |c:5| |
|---|
| Structure | 
|
|---|
Search and Browse
