Reaction Details |
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Target | C-C chemokine receptor type 8 |
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Ligand | BDBM50414980 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_594037 (CHEMBL1045844) |
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IC50 | 2.82±n/a nM |
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Citation | Shamovsky, I; de Graaf, C; Alderin, L; Bengtsson, M; Bladh, H; Börjesson, L; Connolly, S; Dyke, HJ; van den Heuvel, M; Johansson, H; Josefsson, BG; Kristoffersson, A; Linnanen, T; Lisius, A; Männikkö, R; Nordén, B; Price, S; Ripa, L; Rognan, D; Rosendahl, A; Skrinjar, M; Urbahns, K Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites. J Med Chem52:7706-23 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 8 |
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Name: | C-C chemokine receptor type 8 |
Synonyms: | CCR8 | CCR8_HUMAN | CKRL1 | CMKBR8 | CMKBRL2 |
Type: | PROTEIN |
Mol. Mass.: | 40855.53 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_454278 |
Residue: | 355 |
Sequence: | MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVL
VVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSS
MFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGV
LQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLV
LIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIY
AFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
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BDBM50414980 |
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n/a |
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Name | BDBM50414980 |
Synonyms: | CHEMBL568294 |
Type | Small organic molecule |
Emp. Form. | C29H40N4O2 |
Mol. Mass. | 476.6535 |
SMILES | CC(C)(C)C1(C)Cc2c(O1)cccc2CN1CCC2(CC1)CCN(CC2)C(=O)c1ccc(N)cn1 |
Structure |
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