| Reaction Details |
|---|
 | Report a problem with these data |
| Target | C-C chemokine receptor type 8 |
|---|
| Ligand | BDBM50414982 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_594037 (CHEMBL1045844) |
|---|
| IC50 | 2.63±n/a nM |
|---|
| Citation |  Shamovsky, I; de Graaf, C; Alderin, L; Bengtsson, M; Bladh, H; Börjesson, L; Connolly, S; Dyke, HJ; van den Heuvel, M; Johansson, H; Josefsson, BG; Kristoffersson, A; Linnanen, T; Lisius, A; Männikkö, R; Nordén, B; Price, S; Ripa, L; Rognan, D; Rosendahl, A; Skrinjar, M; Urbahns, K Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites. J Med Chem52:7706-23 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| C-C chemokine receptor type 8 |
|---|
| Name: | C-C chemokine receptor type 8 |
|---|
| Synonyms: | CCR8 | CCR8_HUMAN | CKRL1 | CMKBR8 | CMKBRL2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 40855.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_454278 |
|---|
| Residue: | 355 |
|---|
| Sequence: | MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVL
VVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSS
MFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGV
LQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLV
LIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIY
AFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
|
|
|
|---|
| BDBM50414982 |
|---|
| n/a |
|---|
| Name | BDBM50414982 |
|---|
| Synonyms: | CHEMBL579072 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H32F2N4O2 |
|---|
| Mol. Mass. | 470.5547 |
|---|
| SMILES | CC1(C)Oc2c(cccc2CN2CCC3(CC2)CCN(CC3)C(=O)c2ccc(N)cn2)C1(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
