| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Progesterone receptor |
|---|
| Ligand | BDBM50415020 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_600189 (CHEMBL1045526) |
|---|
| IC50 | 2.51±n/a nM |
|---|
| Citation |  Wang, Y; Duraiswami, C; Madauss, KP; Tran, TB; Williams, SP; Deng, SJ; Graybill, TL; Hammond, M; Jones, DG; Grygielko, ET; Bray, JD; Thompson, SK 2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2',3':4,5]thieno[2,3-b]pyridine derivatives as selective progesterone receptor agonists. Bioorg Med Chem Lett19:4916-9 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Progesterone receptor |
|---|
| Name: | Progesterone receptor |
|---|
| Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 98979.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06401 |
|---|
| Residue: | 933 |
|---|
| Sequence: | MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
|
|
|
|---|
| BDBM50415020 |
|---|
| n/a |
|---|
| Name | BDBM50415020 |
|---|
| Synonyms: | CHEMBL570708 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H11Cl2N3OS |
|---|
| Mol. Mass. | 388.27 |
|---|
| SMILES | Cc1c(C#N)c(Cl)nc2c3C(CC(=O)Nc3sc12)c1ccccc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
