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TargetAlpha-2C adrenergic receptor
LigandBDBM50027060
Substrate/Competitorn/a
Meas. Tech.ChEMBL_595091 (CHEMBL1047077)
Ki 550±n/a nM
Citation Cardinaletti, C; Mattioli, L; Ghelfi, F; Del Bello, F; Giannella, M; Bruzzone, A; Paris, H; Perfumi, M; Piergentili, A; Quaglia, W; Pigini, M Might adrenergic alpha2C-agonists/alpha2A-antagonists become novel therapeutic tools for pain treatment with morphine? J Med Chem52:7319-22 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alpha-2C adrenergic receptor
Name:Alpha-2C adrenergic receptor
Synonyms:ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic alpha2C | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens]
Type:Enzyme
Mol. Mass.:49552.32
Organism:Homo sapiens (Human)
Description:P18825
Residue:462
Sequence:
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGF
LIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFG
QVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISA
VISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLR
TRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGA
LRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRR
RRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFK
FFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50027060
n/a
NameBDBM50027060
Synonyms:2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imidazole | 2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imidazole (cirazoline) | CHEMBL13852 | CIRAZOLINE
TypeSmall organic molecule
Emp. Form.C13H16N2O
Mol. Mass.216.2789
SMILESC(Oc1ccccc1C1CC1)C1=NCCN1 |t:13|
Structure
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