| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 10 |
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| Ligand | BDBM50172920 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_621739 (CHEMBL1108471) |
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| IC50 | 1.26±n/a nM |
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| Citation |  Christopher, JA; Atkinson, FL; Bax, BD; Brown, MJ; Champigny, AC; Chuang, TT; Jones, EJ; Mosley, JE; Musgrave, JR 1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3. Bioorg Med Chem Lett19:2230-4 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 10 |
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| Name: | Mitogen-activated protein kinase 10 |
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| Synonyms: | JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52586.89 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 464 |
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| Sequence: | MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
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| BDBM50172920 |
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| n/a |
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| Name | BDBM50172920 |
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| Synonyms: | 3-(6-(2-chlorophenylamino)-1H-indazol-3-yl)-N-(piperidin-4-yl)benzamide | 3-[6-(2-Chloro-phenylamino)-1H-indazol-3-yl]-N-piperidin-4-yl-benzamide | CHEMBL194806 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24ClN5O |
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| Mol. Mass. | 445.944 |
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| SMILES | Clc1ccccc1Nc1ccc2c(n[nH]c2c1)-c1cccc(c1)C(=O)NC1CCNCC1 |
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| Structure | 
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