| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mineralocorticoid receptor |
|---|
| Ligand | BDBM50415796 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_625092 (CHEMBL1112541) |
|---|
| EC50 | >10000±n/a nM |
|---|
| Citation |  Rimland, J; Dunne, A; Hunjan, SS; Sasse, R; Uings, I; Montanari, D; Caivano, M; Shah, P; Standing, D; Gray, D; Brown, D; Cairns, W; Trump, R; Smith, PW; Bertheleme, N; D'Alessandro, P; Gul, S; Vimal, M; Smith, DN; Watson, SP The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist. Bioorg Med Chem Lett20:2340-3 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mineralocorticoid receptor |
|---|
| Name: | Mineralocorticoid receptor |
|---|
| Synonyms: | MCR | MCR_HUMAN | MLR | MR | NR3C2 | Nuclear receptor subfamily 3 group C member 2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 107076.42 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P08235 |
|---|
| Residue: | 984 |
|---|
| Sequence: | METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNST
QGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYE
QQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAV
VKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPN
VENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSP
ANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVP
SPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSD
SSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGF
DGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSAR
DQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPS
KICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRL
QKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVN
TALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQV
VKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKM
HQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYI
KELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAML
VEIISDQLPKVESGNAKPLYFHRK
|
|
|
|---|
| BDBM50415796 |
|---|
| n/a |
|---|
| Name | BDBM50415796 |
|---|
| Synonyms: | CHEMBL1089350 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H21ClN4O |
|---|
| Mol. Mass. | 368.86 |
|---|
| SMILES | CCc1nn(C)c2ncc(C(=O)NCC3Cc4ccccc4C3)c(Cl)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
