| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
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| Ligand | BDBM50118744 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_634028 (CHEMBL1118001) |
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| Ki | 14125.38±n/a nM |
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| Citation |  Cheng, Y; Zhou, M; Tung, CH; Ji, M; Zhang, F Studies on two types of PTP1B inhibitors for the treatment of type 2 diabetes: Hologram QSAR for OBA and BBB analogues. Bioorg Med Chem Lett20:3329-37 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 1 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
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| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 49963.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant GST-fusion PTP1B (1-435). |
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| Residue: | 435 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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| BDBM50118744 |
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| n/a |
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| Name | BDBM50118744 |
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| Synonyms: | 2-(Oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid | 2-(carboxyformamido)-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxylic acid | CHEMBL138806 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H9NO6S |
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| Mol. Mass. | 271.247 |
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| SMILES | OC(=O)C(=O)Nc1sc2COCCc2c1C(O)=O |
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| Structure | 
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