| Reaction Details |
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 | Report a problem with these data |
| Target | N-acylethanolamine-hydrolyzing acid amidase |
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| Ligand | BDBM50416530 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_647126 (CHEMBL1217267) |
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| IC50 | 90±n/a nM |
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| Citation |  Solorzano, C; Antonietti, F; Duranti, A; Tontini, A; Rivara, S; Lodola, A; Vacondio, F; Tarzia, G; Piomelli, D; Mor, M Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors. J Med Chem53:5770-81 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-acylethanolamine-hydrolyzing acid amidase |
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| Name: | N-acylethanolamine-hydrolyzing acid amidase |
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| Synonyms: | ASAH-like protein | Asahl | N-acylethanolamine acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase | N-acylethanolamine-hydrolyzing acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylsphingosine amidohydrolase-like | NAAA_RAT | Naaa |
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| Type: | Enzyme |
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| Mol. Mass.: | 40306.53 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q5KTC7 |
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| Residue: | 362 |
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| Sequence: | MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHY
DPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVL
VNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFV
GYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVY
TLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVP
KRDDRRTPAIKALNATGQAHLSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRN
PS
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| BDBM50416530 |
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| n/a |
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| Name | BDBM50416530 |
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| Synonyms: | CHEMBL1214444 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15NO4 |
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| Mol. Mass. | 297.3053 |
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| SMILES | O=C(N[C@H]1COC1=O)c1ccc(OCc2ccccc2)cc1 |r| |
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| Structure | 
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