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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Muscarinic acetylcholine receptor M1 | ||
| Ligand | BDBM50416727 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_652863 (CHEMBL1226066) | ||
| EC50 | 12.59±n/a nM | ||
| Citation |  Johnson, DJ; Forbes, IT; Watson, SP; Garzya, V; Stevenson, GI; Walker, GR; Mudhar, HS; Flynn, ST; Wyman, PA; Smith, PW; Murkitt, GS; Lucas, AJ; Mookherjee, CR; Watson, JM; Gartlon, JE; Bradford, AM; Brown, F The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists. Bioorg Med Chem Lett20:5434-8 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Muscarinic acetylcholine receptor M1 | |||
| Name: | Muscarinic acetylcholine receptor M1 | ||
| Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51442.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11229 | ||
| Residue: | 460 | ||
| Sequence: |
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| BDBM50416727 | |||
| n/a | |||
| Name | BDBM50416727 | ||
| Synonyms: | CHEMBL1223864 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H32N2O5S | ||
| Mol. Mass. | 436.565 | ||
| SMILES | CCO[C@H]1CC[C@@](C)(CC1)N1CCC(CC1)n1c2cc(ccc2oc1=O)S(C)(=O)=O |r,wD:3.2,6.6,(19.47,-2.31,;18.72,-3.65,;17.18,-3.67,;16.42,-5.01,;14.88,-5.04,;14.13,-6.38,;14.92,-7.7,;13.37,-7.7,;16.46,-7.68,;17.21,-6.34,;14.16,-9.04,;14.95,-10.36,;14.21,-11.7,;12.67,-11.73,;11.87,-10.41,;12.62,-9.07,;11.93,-13.08,;10.45,-13.56,;9.12,-12.8,;7.79,-13.57,;7.78,-15.13,;9.12,-15.89,;10.45,-15.13,;11.93,-15.6,;12.84,-14.34,;14.38,-14.35,;6.46,-12.8,;5.12,-13.57,;5.12,-12.03,;7.54,-11.7,)| | ||
| Structure | 
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