Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M5

Ligand

BDBM50416733

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_652867 (CHEMBL1226070)

EC50

19.95±n/a nM

Citation

Johnson, DJ; Forbes, IT; Watson, SP; Garzya, V; Stevenson, GI; Walker, GR; Mudhar, HS; Flynn, ST; Wyman, PA; Smith, PW; Murkitt, GS; Lucas, AJ; Mookherjee, CR; Watson, JM; Gartlon, JE; Bradford, AM; Brown, F The discovery of a series of N-substituted 3-(4-piperidinyl)-1,3-benzoxazolinones and oxindoles as highly brain penetrant, selective muscarinic M1 agonists. Bioorg Med Chem Lett20:5434-8 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M5

Name:

Muscarinic acetylcholine receptor M5

Synonyms:

ACM5_HUMAN | CHRM5

Type:

PROTEIN

Mol. Mass.:

60102.35

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1517990

Residue:

532

Sequence:

MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ
LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN
LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL
DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE
KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL
TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN
YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP
NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG
YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP

BDBM50416733

n/a

Name

BDBM50416733

Synonyms:

CHEMBL1223803

Type

Small organic molecule

Emp. Form.

C24H36N2O2

Mol. Mass.

384.5548

SMILES

CCCO[C@H]1CC[C@@](C)(CC1)N1CCC(CC1)N1C(=O)Cc2ccc(C)cc12 |r,wD:4.3,7.7,(20.54,1.43,;19,1.41,;18.25,.07,;16.71,.05,;15.96,-1.29,;14.42,-1.31,;13.66,-2.66,;14.45,-3.97,;12.91,-3.97,;15.99,-3.95,;16.74,-2.62,;13.7,-5.32,;14.49,-6.64,;13.74,-7.98,;12.2,-8.01,;11.41,-6.69,;12.16,-5.34,;11.47,-9.36,;12.38,-10.62,;13.92,-10.62,;11.47,-11.88,;9.99,-11.4,;8.65,-12.17,;7.32,-11.4,;7.32,-9.84,;5.99,-9.07,;8.65,-9.08,;9.98,-9.84,)|

Structure