| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-2C adrenergic receptor |
|---|
| Ligand | BDBM50417353 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_684822 (CHEMBL1286052) |
|---|
| EC50 | 112±n/a nM |
|---|
| Citation |  Del Bello, F; Mattioli, L; Ghelfi, F; Giannella, M; Piergentili, A; Quaglia, W; Cardinaletti, C; Perfumi, M; Thomas, RJ; Zanelli, U; Marchioro, C; Dal Cin, M; Pigini, M Fruitful adrenergica(2C)-agonism/a(2A)-antagonism combination to prevent and contrast morphine tolerance and dependence. J Med Chem53:7825-35 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-2C adrenergic receptor |
|---|
| Name: | Alpha-2C adrenergic receptor |
|---|
| Synonyms: | ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic alpha2C | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens] |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49552.32 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P18825 |
|---|
| Residue: | 462 |
|---|
| Sequence: | MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGF
LIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFG
QVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISA
VISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLR
TRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGA
LRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRR
RRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFK
FFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
|
|
|
|---|
| BDBM50417353 |
|---|
| n/a |
|---|
| Name | BDBM50417353 |
|---|
| Synonyms: | CHEMBL242265 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H18N2O |
|---|
| Mol. Mass. | 266.3376 |
|---|
| SMILES | C[C@@H](Oc1ccccc1-c1ccccc1)C1=NCCN1 |t:17| |
|---|
| Structure | 
|
|---|
Search and Browse
