Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50417499 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_685890 (CHEMBL1292646) | ||
| Ki | 63.1±n/a nM | ||
| Citation |  Tellew, JE; Lanier, M; Moorjani, M; Lin, E; Luo, Z; Slee, DH; Zhang, X; Hoare, SR; Grigoriadis, DE; St Denis, Y; Di Fabio, R; Di Modugno, E; Saunders, J; Williams, JP Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties. Bioorg Med Chem Lett20:7259-64 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
| ||
| BDBM50417499 | |||
| n/a | |||
| Name | BDBM50417499 | ||
| Synonyms: | CHEMBL1287848 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H22N6O2 | ||
| Mol. Mass. | 378.4277 | ||
| SMILES | COc1ccc(-c2c(C)nn3c(NCc4nc(C)no4)cc(C)nc23)c(C)c1 |(6.38,-31.64,;4.84,-31.6,;4.1,-30.25,;2.56,-30.2,;1.84,-28.87,;2.63,-27.55,;1.89,-26.2,;2.79,-24.96,;4.33,-24.95,;1.88,-23.72,;.43,-24.19,;-.91,-23.43,;-.91,-21.89,;-2.31,-21.25,;-3.57,-22.14,;-5.03,-21.65,;-5.94,-22.86,;-7.48,-22.84,;-5.06,-24.13,;-3.58,-23.68,;-2.25,-24.2,;-2.24,-25.75,;-3.57,-26.52,;-.9,-26.5,;.43,-25.73,;4.17,-27.59,;4.97,-26.27,;4.91,-28.95,)| | ||
| Structure | 
| ||