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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50417500 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_685890 (CHEMBL1292646) | ||
| Ki | 5.01±n/a nM | ||
| Citation |  Tellew, JE; Lanier, M; Moorjani, M; Lin, E; Luo, Z; Slee, DH; Zhang, X; Hoare, SR; Grigoriadis, DE; St Denis, Y; Di Fabio, R; Di Modugno, E; Saunders, J; Williams, JP Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties. Bioorg Med Chem Lett20:7259-64 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50417500 | |||
| n/a | |||
| Name | BDBM50417500 | ||
| Synonyms: | CHEMBL1287877 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H26N6O2 | ||
| Mol. Mass. | 406.4808 | ||
| SMILES | CCN(Cc1nc(C)no1)c1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C |(18.29,-22.05,;16.95,-21.3,;15.64,-22.08,;14.29,-21.33,;13.03,-22.21,;11.57,-21.7,;10.65,-22.92,;9.11,-22.88,;11.52,-24.19,;13,-23.75,;15.65,-23.62,;14.32,-24.41,;14.34,-25.95,;13.02,-26.74,;15.69,-26.7,;17.01,-25.91,;18.48,-26.37,;19.37,-25.12,;20.91,-25.1,;18.45,-23.89,;17,-24.38,;19.19,-27.74,;18.37,-29.04,;19.07,-30.39,;20.61,-30.47,;21.31,-31.83,;22.86,-31.91,;21.44,-29.18,;20.73,-27.81,;21.56,-26.51,)| | ||
| Structure | 
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