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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Corticotropin-releasing factor receptor 1 | ||
| Ligand | BDBM50417502 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_685890 (CHEMBL1292646) | ||
| Ki | 10±n/a nM | ||
| Citation |  Tellew, JE; Lanier, M; Moorjani, M; Lin, E; Luo, Z; Slee, DH; Zhang, X; Hoare, SR; Grigoriadis, DE; St Denis, Y; Di Fabio, R; Di Modugno, E; Saunders, J; Williams, JP Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties. Bioorg Med Chem Lett20:7259-64 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Corticotropin-releasing factor receptor 1 | |||
| Name: | Corticotropin-releasing factor receptor 1 | ||
| Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50744.31 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P34998 | ||
| Residue: | 444 | ||
| Sequence: |
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| BDBM50417502 | |||
| n/a | |||
| Name | BDBM50417502 | ||
| Synonyms: | CHEMBL1287905 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H26N6O2 | ||
| Mol. Mass. | 406.4808 | ||
| SMILES | CC[C@@H](Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1C)c1nc(C)no1 |r,wU:2.2,(12.72,-33.43,;14.06,-34.18,;14.08,-35.71,;15.43,-36.46,;15.45,-38.01,;14.11,-38.8,;14.13,-40.34,;12.81,-41.13,;15.48,-41.08,;16.8,-40.3,;18.27,-40.76,;19.16,-39.51,;20.7,-39.48,;18.24,-38.27,;16.79,-38.76,;19.05,-42.09,;18.28,-43.43,;19.04,-44.74,;20.58,-44.75,;21.35,-46.08,;22.9,-46.08,;21.35,-43.42,;20.58,-42.08,;21.35,-40.75,;12.85,-36.64,;11.38,-36.18,;10.5,-37.42,;8.96,-37.45,;11.41,-38.66,;12.88,-38.18,)| | ||
| Structure | 
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